Acute Lymphoblastic Leukemia: Genetic Events and Molecular Signatures

¹ State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, P. R. China.

²Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, U.S.A.

*Corresponding author:

Yiguo Hu

State Key Laboratory of Biotherapy

West China Hospital, West China Medical School, Sichuan University

Chengdu, Sichuan 610041

P. R. China

Fax: (86)-28-85164060

Email: huyiguo99@gmail.com

Abstract

Childhood or pediatric acute precursor B cell lymphoblastic leukemia (B-ALL) is the most prevalent hematological malignancy in children. Previous studies have revealed relationships between genetic lesions and the disease. In this review, I discuss our current understanding of the genetic lesions and molecular events in childhood B-ALL and the related therapeutic implications.

Keywords: ALL, Genetics, Translocations, Alterations, Mutations, Prognosis.

Download the full article (PDF)