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Am. J. Biomed. Sci. Am. J. Biomed. Sci. 2017, 9(4), 200-210; doi:10.5099/aj170400200
Received: 02 August 2017; | Revised: 05 September 2017; | Accepted: 18 December 2017

 

Is Marijuana Beneficial for Prevention and Treatment of Diabetes?

 

Rui Cao1,2*, Jun Wang1*#, Wei Zhang1, Huang Huang1, Yu Qiao3, Yufan Dai4,

Miaozi Gong5, Hong C. Lai6

1Department of Pharmacology, Bioengineering and Food College, Hubei University of Technology, Wuhan, Hubei 430068, China

2Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA

3Research Institute of Agricultural Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan 430064, China

4School of Physics and Technology, Wuhan University, Wuhan 430072, China

5Department of Pathology, Peking University Shougang Hospital, Beijing 100144, China
6Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA

*These two authors contribute equally to this paper.

#Corresponding Author

Jun Wang

Department of Pharmacology

Bioengineering and Food College

Hubei University of Technology

Wuhan, Hubei 430068

China

Email: 2491549178@qq.com

 

Abstract

Marijuana is classified as Cannabis saiva L, one type of hemp. Traditionally, Marijuana is considered as Schedule I drug due to its acute bad effects on human health. However, its medical use has been widely recognized today. Delta-9-tetrahydrocannabinol (D9-THC) is a compound extracted from Marijuana, which has been used in several drugs approved by United States Food and Drug Administration (FDA). D9-THC functions through cannabinoid receptor in neural system or peripheral tissues. For diabetes patients, D9-THC has been reported to have preventative or treatment effects. In this paper, we will review recent research progress in association between cannabis use and diabetes, as well as known mechanism of how D9-THC functions in human from the perspective of free radicals.

Keywords: cannabis, diabetes, Delta-9-tetrahydrocannabinol, free radicals

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