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Am. J. Biomed. Sci. 2017, 9(4), 237-243; doi:10.5099/aj170400237
Received: 18 November 2017; | Revised:05 December 2017; | Accepted: 21 December 2017

 

Immunohistochemical Correlation between the Expression of Vitamin D receptor (VDR) and Triple Negative Invasive Ductal Carcinoma Tissues

 

*1Fasogbon, Samuel Ayobami 2Okechi, O. O. 3Adisa, James O. 4 Madukwe, Jonathan U.

1Public Health In-vitro Diagnostic Control Laboratory, Medical Laboratory Science Council of Nigeria, Yaba-Lagos, Nigeria

2College of Medicine and Health Sciences, Abia State University, Uturu, Nigeria

3Department of Medical Laboratory Science, University of Jos. Jos, Nigeria

4Department of Histopathology, National Hospital Abuja, Nigeria

*Corresponding Author

Fasogbon, Samuel Ayobami

Public Health In-vitro Diagnostic Control Laboratory,

Medical Laboratory Science Council of Nigeria,

8, Harvey Road, Yaba, Lagos State

Nigeria.

E-mail: samfash4best@gmail.com

Cell Phone: +2348032229904         

 

Abstract

Aim: The study was carried out to determine the Immunohistochemical Correlation between the Expression of Vitamin D Receptor (VDR) and Triple Negative Invasive Ductal Carcinoma (IDC) tissues Materials and Method: Twenty two (22) cases of archived female breast Invasive Ductal Carcinoma tissue blocks that are Negative to ER, PR, and HER-2 (Triple Negative) were used. The tissue blocks were sectioned at not more than 2┬Ám each. Haematoxylin and Eosin staining method and immunohistochemical staining technique using VDR antibodies were done and the results were correlated. Result and Discussion: The results show that there is a significant difference (P<0.05) found comparing the immunohistochemical expression of VDR with Triple Negative IDC tissues but strong positivity is shown in VDR positive IDC tissues. Conclusion: There is a statistically significant difference found in the expression of VDR with Triple negative IDC tissues; therefore VDR cannot be use as substitute in cases of triple negative IDC tissues but can be an additional antibody and of therapeutic target in breast cancer.

Keywords: Vitamin D receptor (VDR), Triple Negative, Invasive ductal carcinoma (IDC), Breast Cancer

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