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Am. J. Biomed. Sci. 2018, 10(1), 18-27; doi:10.5099/aj180100018
Received:15 December 2017 ; | Revised:28 December 2017; | Accepted: 12 March 2018

 

Assessing Lipoprotein Levels in Normotensive and Hypertensive Pregnant Women in Port Harcourt, Nigeria

 

*Oladapo-Akinfolarin, Tomaziga Tomiloba; Bartimeaus, Ebirien-Agana Samuel; Nwachuku,

Edna.Ogechi and Nduka, Nsirim

Department of Medical Laboratory Science, Rivers State University, PM.B. 5080, Nkpolu Oroworukwo, Port Harcourt, Nigeria.

*Corresponding Author

Oladapo-Akinfolarin, Tomaziga Tomiloba

Department of Medical Laboratory Science

Rivers State University

PM.B. 5080, Nkpolu Oroworukwu

Port Harcourt

Nigeria

Email: ola_atomaziga@yahoo.com

 

Abstract

Background: Lipids and lipoproteins are central to the energy metabolism of the liver, and have continued to be important in clinical practice; basically because of their association with Coronary Heart Disease (CHD). Abnormal lipid metabolism is linked to atherosclerosis due to rising incidence of abdominal obesity.

Objective: To evaluate some cardiovascular disease risk status such as lipid profile of pregnant Normotensive and Hypertensive women and compare it with the corresponding levels in Non pregnant Normotensive women.

Method: This study was conducted in the Department of Medical Laboratory Science, Rivers State University, Port Harcourt, Nigeria .A total of 300 women were registered for the study after taking informed consent. 100 of them were pregnant hypertensives,100 pregnant Normotensives and 100 Non pregnant normotensives as control. All relevant information was recorded on a predesigned questionnaire. Serum total cholesterol (TC), High-density lipoprotein (HDL-C), low density lipoprotein cholesterol (LDL-C), very lowdensity lipoprotein cholesterol(VLDL-C) and Triglyceride levels were measured in the 200 women, including systolic and diastolic blood pressure (SBP & DBP) and BMI; and compared with that of the 100 non pregnant Normotensive women.

Result: Total Cholesterol levels were not statistically significant between the subject groups and control. Mean values of TG, HDL-C, LDL-C and VLDL-C were significant at p<0.05. Age, BMI, SBP and DBP were also significant at p<0.05. BMI, SBP and DBP, TG, HDL and VLDL were statistically significant when HPW were compared with NPW. Age, BMI, SBP and DBP, TG, HDL-C and LDL-C were statistically significant when HPW were compared with NNPW. Only, BMI and TG were statistically significant at 19 P<0.05 when NPW were compared with NNPW. 90% of HPW at 38.72±6.56, 14% of NPW at 36.16±12.74, and 2% of NNPW at 31.38±0.88 were obese. HPW and NPW had higher ratios of TG: HDL (75% and 74%) compared to NNPW of 10%. NPW and NNPW had higher ratios of TC: HDL (65% and 48%) compared to HPW of 4%. NPW and HPW had higher ratio of LDL: HDL (17% and 14%) compared to NNPW of 13%.

Conclusion: Lipoprotein levels and ratios are higher in hypertensive and Normotensive pregnant women, than in Normotensive Non pregnant women; thereby, exposing them to cardiovascular risks in the near future.

 

Keywords: Hypertensive, Normotensive, pregnant women

 

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