Pathophysiological Assessment of Bisephenol A and Di (2-ethylhexyl)Phthalate

on Hepatic and Renal Function Parameters of Albino Wistar Rats 

¹Health Services Department, University Of Benin, Ugbowo, Benin City, Nigeria

²Department Of Medical Laboratory Sciences, University Of Nigeria, Enugu Campus, Enugu, Nigeria

³Department Of Medical Laboratory Sciences, Enugu State University Teaching, Parklane, Enugu State, Nigeria

^*Corresponding Author

Nosa Terry Omorodion

Health Services Department, University Of Benin,

Ugbowo, Benin City,

Nigeria 

Email: terry.omorodion@uniben.edu

Phone:+2348136742270

Abstract

The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks of particular concern are the use of endocrine-disrupting chemicals (EDCs) in plastic production, including Di(2-ethylhexyl) phthalate (DEHP) and Bisphenol A (BPA). The aim of this work is to evaluate the pathological effect of bisephenol a and di(2-etylhexyl)phthalate on weight, liver and liver function parameters of albino wistar rats. An experimental study involving 60 Wistar rats was carried out. The rats were divided into four groups of 15 Wistar rat each in a group. The group I received normal rats pellet and water and served as control group, group II received 5mg/kg/day of BPA mixed with rat pellet orally, group III received 0.5mg/kg daily of DEHP mixed with rat pellet while group IV received orally mixture of 0.5mg/kg BPA and 0.5mg/kg DEHP + rat pellet. The rats were fed for 30 consecutive days after which they were sacrificed and an analysis was carried out on them. The laboratory analysis revealed significant variations in the concentration of liver function test, kidney function test and weight size in group II, III, and IV comparison with group I (control). In conclusion, the present work reveals that Bpa and Dehp alters the proper functioning of the hepatic and renal functioning and can also lead to severe weight loss.

Keywords: Liver, Kidney, Bisephenol A, Di (2-ethylhexyl)phathalate 

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