A Novelty-Induced Integrated Environmental Challenge to Assess Sedative-Anxiolytic Potential of Lychee (Litchi Chinensis) Honey

¹Department of Pharmacology, Institute for Pharmaceutical Skill Development and Research, Bangladesh

²Department of Genetic Engineering and Biotechnology, East West University, Bangladesh

³Department of Anesthesiology, Bangabandhu Sheikh Mujib Medical University, Bangladesh

⁴Department of Pharmacy, University of Asia Pacific, Bangladesh

⁵Consultant Paediatrician, Tripoli Children Hospital, Tripoli, Libya

^*Corresponding Author

Mohammad M. Billah

Department of Pharmacology

Institute for Pharmaceutical Skill Development and Research

Bangladesh

Email: mustakimbillah@hotmail.com

Abstract

The assessment of neuropharmacological potential has always been challenging due to the variance found with different subjects, in different time intervals. Therefore, the present study was aimed to introduce a new approach by integrating behavioral fields together which allowed to utilize the same rodent for different experiments at the same time to minimize the variances. Experiments through Open Field, Hole Cross and Elevated Plus Maze fields were designed in such a way that same subject can experience all fields subsequently at the consecutive time intervals. Lychee honey at doses 2g/kg, 4g/kg and 6g/kg body weight was orally administered to Swiss Albino mice and their sedative and anxiolytic potential was evaluated against diazepam (1mg/Kg). At all doses the honey found to be highly effective as significantly reduced the locomotor and other exploratory activities. The data implied that the honey may act through the GABAA receptors and can prove as a potential source for neuro drug research.

Keywords:Open Field, Hole Cross, Elevated Plus Maze, Rearing, Grooming, Lychee Honey

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