Glyceamic and Oxidative Stress Markers in Different Haptoglobin Phenotypes of A Type-2 Diabetics’ Population in Nigeria

¹ Department of Chemical Pathology, Osun State University, Osogbo, Osun State

² Department of Medical Laboratory Science, Afe-Bablola University, Ado-Ekiti, Ekiti State

³ Department of Medical Laboratory Science , University of Benin, Benin City, Edo State

^*Corresponding Author

O.O. Olaniyan

Department of Chemical Pathology,

Osun State University,

Osogbo, Osun State

Nigeria

Cell Phone: +2348034766014

Email:olacube2001@gmail.com

Abstract

Diabetes has long been known to be synonymous with body oxidative stress and development of vascular complications. Different clinical functions including oxidative capabilities have been credited to the different haptoglobin polymorphism. This study is aimed at finding possible association between haptoglobin gene polymorphism, glyceamic control indices and antioxidants parameters in Nigerian type 2 diabetics. The study included 170 subjects divided into three groups of 60 type 2 diabetics without any vascular complications, 60 type 2 diabetics with various vascular complications, and 50 age and sex matched apparently healthy subjects. All participants were subjected to full history taking, complete clinical examination, and routine laboratory investigations. Haptoglobin phenotypes, glyceamic control index and antioxidant parameters were measured in all subjects. Hp1-1 polymorphic type 2 diabetics show good glyceamic control indices than Hp2-1 and Hp 2-2 individuals. Likewise, Hp2-2 polymorphic type 2 diabetics show significantly reduced antioxidant potentials than Hp2-1 and Hp1-1 polymorphic individuals. Hp 2-2 polymorphism is a likely genetic predisposing factor contributing to development of diabetes vascular complications via low antioxidant level. Awareness of this gene susceptibility should raise future research for proper treatment and prevention of vascular complications in diabetics.

Keywords: Haptoglobin polymorphism, Antioxidant, type 2 diabetes, Vascular complications, Glyceamic control

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