Hydrolyzed Collagen-Based Hydrogel System Design, Characterization and Application in Drug Delivery

^aPolymer Research Unit, Department of Chemistry, Utkal University, Vani Vihar, Bhubaneswar, India

^bPolymer Research Unit, Department of Chemistry, M.P. Mahavidyalaya College, Erakana, India

^cP.G. Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, India

§: These authors contributed equally to this work.

*Corresponding Author:

Palapparambil Sunny Gils

Polymer Research Unit

Department of Chemistry

Utkal University

Vani Vihar, Bhubaneswar 751004

India

Email: gils.ps@gmail.com

       This work was intended to develop a new hydrogel of collagen-g-Poly (acrylamide-co-itaconic acid) through chemical cross-linking by graft copolymerization of acrylamide (AM) and itaconic acid (IA) on to collagen (CGN) via redox initiator system of ammonium persulfate (APS) and N, N, N', N'-tetramethylethylenediamine (TMED), in presence of N, N'-methylene bis acrylamide (MBA) as crosslinking agent. Characterization of the hydrogel was done by FT-IR, TGA, SEM, LCMS/MS and HPLC. Valsartan (VAL) was successfully loaded into the prepared hydrogel. CGN-g-P(AM-co-IA) (H₁₀) formulation showed highest swelling capacity as well as VAL release in the biological media and release was controlled up to 24h. The release data of various formulations were fitted to Zero order, First order and Higuchi’s kinetic models. It was observed that the release of drug from all the formulations followed Higuchi's kinetic model as its value of coefficient of determination is greater than that of others.

Keywords: Hydrogel, Collagen, Acrylamide, Itaconic acid, Residual monomers, Valsartan delivery.

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