Calcium Phosphate Scaffold Loaded with Platinum Nanoparticles for Bone Allograft

^{1, 4,5}Department of Chemistry, Faculty of Science, Suez Canal University, Suez, Egypt  

²Department of Biomedical Engineering, Higher Technology Institute, HTI, 10^th of Ramadan City, EGYPT

³Applied Research Sector, Egy-Vac/ VACSERA, 22311, (1), EGYPT

^*Corresponding author:

Kamel A.M. Eid

School of Sciences & Engineering

The American University In Cairo

AUC Avenue, SSE # 1184

P.O. Box 74

New Cairo, Egypt 11835

Fax: +2 022795 7565

E-mail: kamelam@aucegypt.edu

Abstract

Inflammations are a predicament issue that leads to orthopaedic hard implants failure. Thereby, calcium phosphate platinum scaffolds possess anti-inflammatory properties, as powerful tools for successful bone regeneration. The effects of the platinum nanoparticles (PtNPs) on the scaffold's degradation and proliferation and attachment were evaluated. The scaffolds degradation rates ranged between 50-75 % and 80-95% for Scaffold with and without PtNPs respectively. Moreover, the cells proliferation and attachment on CPs-PtNPs scaffold were superior to CPs scaffold. The results warranted that, the synthesized scaffolds exhibit good biocompatibility and in vitro biodegradation, and also, it could be a used as a substrate for PtNPs delivery.

Keywords: Platinum Nanoparticles, Tissue Engineering, Bone Grafting, Calcium Phosphate.

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