Recent Advances in Nanoparticles-based Lateral Flow Biosensors

¹Research Center for Bioengineering and Sensing Technology, University of Science & Technology Beijing, Beijing,

P. R. China

²Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, FL, USA

³Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND, USA

*Corresponding Author

Dr Li-Ping Xu

Research Center for Bioengineering and Sensing Technology

University of Science & Technology Beijing

Beijing, 100083

P. R. China

Tel.: +86 10-8237-6831

E-mail: xuliping@ustb.edu.cn

Dr Xueji Zhang

Research Center for Bioengineering and Sensing Technology

University of Science & Technology Beijing

Beijing, 100083

P. R. China

Tel.: +86 10-8237-6993

E-mail: zhangxueji@ustb.edu.cn

Abstract

Lateral flow biosensors (LFBs) provide advantages in low cost, simplicity, rapidity, stability and portability, thus making LFBs popular in biomedical, agriculture, food and environmental sciences. This article reviews recent advances of LFBs for bioassays, including the investigation of the improvements achieved by signal-amplification strategies, the application of new nanoparticle labels, novel quantitative system and simultaneous detection. We summarized the outstanding performances of LFBs such as high detection sensitivity, specificity, reproducibility and reliability.

Keywords: lateral flow biosensor, point-of-care testing, nanoparticles, bioassays.

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