Role of Commiphora Mol Mol and Doxycycline in Prophylaxis of Spontaneous Bacterial Peritonitis in Egyptians Cirrhotic Patients

Gamal Ahmed Abd El-Khalek Badra,² Eman Ibrahim Abd El-Kader El-Berri^1*

¹Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, Egypt

²Department of Hepatology, National Liver Institute, Menofiya University. Shebeen El Kom, Egypt

^*Corresponding Author

Eman Ibrahim Abd El-Kader El-Berri

Demonastrator of Clinical Pharmacy

Department of Clinical Pharmacy

Faculty of Pharmacy

Tanta University

Tanta, 31527, Egypt.

Email: eman.elberri@yahoo.com

Mobil: +2001003592593

Abstract

Aims: this study aimed to evaluate the role of commiphora mol mol and doxycycline in the prophylaxis of spontaneous bacterial peritonitis in cirrhotic patients. Methodology: sixty ascetic cirrhotic patients from National Liver Institute, Menofiya University (Shebeen El-Kom- Egypt) with a history of at least one previous episode of SBP were included in blinded randomized clinical study. Patients were divided into four groups in a fashion; each group consists of 15 patients. Group one received ciprofloxacin (control group), group two received doxycycline, group three received commiphora mol mol and group four received a combination of commiphora mol mol and doxycycline for six months. Serum interleukin 6 (IL 6) and C Reactive Protein (CRP) level were the primary inflammatory markers of the study to evaluate the effect of the studied medications. Results: both IL-6 and CRP levels showed significant decrease three and six months after treatment in all studied groups (P<0.05).Group four showed a significant decrease in IL 6 and CRP level compared with other three groups (P<0.05). Conclusion: the results of the current study strongly support the efficacy of doxycycline and Commiphora molmol as a primary prophylactic therapy in patients with SBP. Furthermore, commiphora mol mol/doxycycline combination was the most effective and showed synergistic effect which may be useful in decrease emergence of resistant strains.

Keywords: Spontaneous bacterial peritonitis; Commiphora mol mol; Doxycycline; IL 6; CRP.

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