Comparative Antidiarrheal Activity of Three Bangladeshi Medicinal Plants Using in Vivo Animal Model Study

Mohammed Abu Sayeed¹, Md. Aslam Hossain²

¹Department of Pharmacy Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong-4203, Bangladesh.

²Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka. Dhaka- 1000, Bangladesh.

^*Corresponding Author

Rashaduz Zaman

Department of Pharmacy

International Islamic University Chittagong

Chittagong-4203

Bangladesh

Cell: +8801822323331

Email: rashad.pharma.iiuc@gmail.com

Abstract

Diarrhea is a worldwide concern. So this study investigated the antidiarrheal effect of methanol extract of leaves of Podocarpus neriifolius D. Don., Mangifera sylvatica Roxb. and Ficus sagittata Vhal. using in vivo animal model. These plants have history of ethnobotanical use. Antidiarrheal effect was assessed in Castor oil induced diarrheal test model in Swiss Albino mice. Lopramide (5 mg/kg) was used as standard drug. The animals were treated with doses of 200 and 400 mg/kg of the plant extracts. All data were analyzed by the software, statistical package for social science (SPSS), Version 18.0. The extracts (200 and 400 mg/kg) showed a remarkable antidiarrheal activity by reducing the number of defecation and maintaining the consistency of faeces. All the extracts significantly (P < 0.001) inhibited the diarrheal incidence at the dose of 200 and 400 mg/kg. Mangifera sylvatica showed the highest percent of inhibition of 72.37% at dose of 400 mg/kg and Ficus sagittata showed the lowest (52.63%) percent of inhibition at dose of 200 mg/kg while the standard Loperamide showed 77.63% of diarrheal inhibition. The results suggest the potentiality of Podocarpus neriifolius, Mangifera sylvatica and Ficus sagittata as antidiarrheal drugs but further investigations are required to find out the exact mechanism of action and the chemicals responsible for the effect.

Keywords: Antidiarrheal, Castor-oil, Podocarpus neriifolius, Ficus sagittata, Mangifera sylvatica, Loperamide.

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