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Am. J. Biomed. Sci. 2016, 8(4), 288-296; doi: 10.5099/aj160400288
Received: 20 June 2016; | Revised: 21 November 2016; | Accepted: 7 December 2016


Hepatitis B Vireamia in Hepatitis B Surface Antigenemic Patients in Bangladesh


Fazley Rabbi Sha1, M Moyen Uddin PK2*, Mohammad Khairul Islam Sarkar3, Rabiul Islam Talukder2, Abdul Hai Siddique4, Kamrun Nahar5, Muhammad Saiedullah6, Yearul Kabir7

1Rajshahi University, Rajshahi 6205, Bangladesh

2Primeasia University, Dhaka 1213, Bangladesh

3Independent University, Bangladesh (IUB)

4Tohoku University, Sendai, Miyagi Prefecture 980-8577, Japan

5Dhaka Medical College Hospital, Dhaka 1000, Bangladesh

6University of Health Sciences, Dhaka 1216, Bangladesh

7University of Dhaka, Dhaka 1000, Bangladesh

*Corresponding Author

M Moyen Uddin PK

Department of Biochemistry
Primeasia University

Rd No 17

Dhaka 1213, Bangladesh
Email: moyen.uddinpk@primeasia.edu.bd



Objectives: This study evaluates the distribution of hepatitis B vireamia in patients with hepatitis B virus (HBV) infection. Methods: HBV-infected patients were enrolled in this study. HBV DNA tests were carried out using Smart Cycler II to detect HBV DNA level in serum samples of all HBsAg-positive patients. Results: The distribution of HBV DNA level was found significantly related to age groups (p<0.05), gender group (p<0.05), ALT group (p<0.05), and HBeAg group (p<0.05). The HBV DNA level was recorded to be significantly higher in the HBeAg-positive group (p<0.05) in compared to the HBeAg-negative group. Conclusions: A low level of viral replication may persevere in chronic HBV-infected patients who are HBeAg-negative, and the level of HBV DNA was higher in the HBeAg-positive group.

Keywords: Hepatitis B, HBV DNA level, HBeAg, ALT

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