Hepatitis B Vireamia in Hepatitis B Surface Antigenemic Patients in Bangladesh

¹Rajshahi University, Rajshahi 6205, Bangladesh

²Primeasia University, Dhaka 1213, Bangladesh

³Independent University, Bangladesh (IUB)

⁴Tohoku University, Sendai, Miyagi Prefecture 980-8577, Japan

⁵Dhaka Medical College Hospital, Dhaka 1000, Bangladesh

⁶University of Health Sciences, Dhaka 1216, Bangladesh

⁷University of Dhaka, Dhaka 1000, Bangladesh

^*Corresponding Author

M Moyen Uddin PK

Department of Biochemistry
Primeasia University

Rd No 17

Dhaka 1213, Bangladesh
Email: moyen.uddinpk@primeasia.edu.bd

Abstract

Objectives: This study evaluates the distribution of hepatitis B vireamia in patients with hepatitis B virus (HBV) infection. Methods: HBV-infected patients were enrolled in this study. HBV DNA tests were carried out using Smart Cycler II to detect HBV DNA level in serum samples of all HBsAg-positive patients. Results: The distribution of HBV DNA level was found significantly related to age groups (p<0.05), gender group (p<0.05), ALT group (p<0.05), and HBeAg group (p<0.05). The HBV DNA level was recorded to be significantly higher in the HBeAg-positive group (p<0.05) in compared to the HBeAg-negative group. Conclusions: A low level of viral replication may persevere in chronic HBV-infected patients who are HBeAg-negative, and the level of HBV DNA was higher in the HBeAg-positive group.

Keywords: Hepatitis B, HBV DNA level, HBeAg, ALT

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