Assessment of Prostate Specific Antigen Level Among Elderly Men in Port-Harcourt City, Nigeria

¹State General Hospital, Ipe-Akoko, Ondo State, Nigeria

²Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State

³Department of Histopathology and Morbid Anatomy, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Osun State

^*Corresponding Author

AJILEYE, Ayodeji Blessing

Department of Medical Laboratory Science

College of Medicine and Health Sciences

Afe Babalola University

Ado Ekiti

Ekiti State

Nigeria

Cell no. +2348030445624

Email: ayobless05@gmail.com

Abstract

Prostate specific antigen is known to be a specific marker for the diagnosis of prostate cancer which is a serine protease enzyme, secreted almost exclusively from the prostate gland. The purpose of carrying out this research work is to assess the level of prostate specific antigen and to know the prevalence of prostate cancer among adult men living in Port-Harcourt City, Nigeria. Eighty (80) apparently healthy elderly men of age 50 years and above were considered appropriately suitable for this research work, after due consultation with each patient, a questionnaire form was given to each of the subjects to fill which help in categorizing the patients into their age groups, patients whose age were below age studied group (50 years and above) and subject who were not apparently healthy were exempted from this research work. Blood samples were collected from the subjects into plane bottles, spun at 3,000 rpm (revolution per minutes), serum was separated and then analyze with a spectrophotometer at 450 nm. Between ages 50 to 59 years, the mean protein specific antigen concentration was 13.12±5.24 ng/ml; between the ages 60 to 69 years, the mean protein specific antigen concentration is 11.39±8.13 ng/ml. while in ages 70 years and above, the mean protein specific antigen concentration is 17.53±10.47 ng/ml. it was observed that about 47.5% of the subjects worked on, had protein specific antigen values within the normal range and about 25% of the subjects are at risk and about 27.5% of the subjects has prostatic cancer with values above 10ng/ml. Base on the assessment of protein specific antigen in Port-Harcourt city, the prevalence of the disease prostate cancer among elderly men is relatively high (hyperplasia).

Keywords: Prostate, Antigen, Protein, Cancer, Enzyme

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