Immunohistochemical Correlation between the Expression of Vitamin D receptor (VDR) and Triple Negative Invasive Ductal Carcinoma Tissues

¹Public Health In-vitro Diagnostic Control Laboratory, Medical Laboratory Science Council of Nigeria, Yaba-Lagos, Nigeria

²College of Medicine and Health Sciences, Abia State University, Uturu, Nigeria

³Department of Medical Laboratory Science, University of Jos. Jos, Nigeria

⁴Department of Histopathology, National Hospital Abuja, Nigeria

^*Corresponding Author

Fasogbon, Samuel Ayobami

Public Health In-vitro Diagnostic Control Laboratory,

Medical Laboratory Science Council of Nigeria,

8, Harvey Road, Yaba, Lagos State

Nigeria.

E-mail: samfash4best@gmail.com

Cell Phone: +2348032229904         

Abstract

Aim: The study was carried out to determine the Immunohistochemical Correlation between the Expression of Vitamin D Receptor (VDR) and Triple Negative Invasive Ductal Carcinoma (IDC) tissues Materials and Method: Twenty two (22) cases of archived female breast Invasive Ductal Carcinoma tissue blocks that are Negative to ER, PR, and HER-2 (Triple Negative) were used. The tissue blocks were sectioned at not more than 2µm each. Haematoxylin and Eosin staining method and immunohistochemical staining technique using VDR antibodies were done and the results were correlated. Result and Discussion: The results show that there is a significant difference (P<0.05) found comparing the immunohistochemical expression of VDR with Triple Negative IDC tissues but strong positivity is shown in VDR positive IDC tissues. Conclusion: There is a statistically significant difference found in the expression of VDR with Triple negative IDC tissues; therefore VDR cannot be use as substitute in cases of triple negative IDC tissues but can be an additional antibody and of therapeutic target in breast cancer.

Keywords: Vitamin D receptor (VDR), Triple Negative, Invasive ductal carcinoma (IDC), Breast Cancer

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