Assessment of the Levels of Parathyroid Hormone, Oestrogen and Selected Bone Minerals in Menopausal Women

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria.

^*Corresponding Author

Dr A.O Oluboyo

Department of Medical Laboratory Science

College of Medicine and Health Sciences

Afe Babalola University, Ado Ekiti

Ekiti State

Nigeria

Email: oluboyoao@abuad.edu.ng

Abstract

Menopause is associated with various physiological and biochemical changes that have effects on bone minerals and their metabolism. There have been a lot of complaints about bone pains and bone related problems especially among middle aged women. Thus, the work was designed to assess and compare the levels of parathyroid hormone (PTH), oestrogen and selected bone minerals (calcium and phosphate) in pre- and post-menopausal women. A total of one hundred subjects were investigated. They comprised fifty pre-menopausal women within the ages of 20 years and 45 years and fifty post-menopausal women within the ages of 50 years and 65 years. The levels of parathyroid hormone, oestrogen, calcium and phosphate were measured in the subjects. Parathyroid hormone and oestrogen were analyzed using enzyme immunoassay technique while calcium and phosphate were analyzed using spectrophotometric method. The results showed that parathyroid hormone, calcium and phosphate were significantly increased (p<0.05) while there was decrease in oestrogen in post-menopausal women compared with premenopausal women. PTH and oestrogen correlated significantly at (p<0.01) in both pre- and post menopause. This study concluded that postmenopausal women have increased serum levels of parathyroid hormone, calcium and phosphate but decreased serum level of oestrogen. Significant positive correlation exists between PTH and oestrogen in both pre- and post menopause but no significant relationship between PTH and oestrogen with calcium and phosphate.

Keywords:Parathyroid hormone, Phosphate, calcium, Oestrogen, Menopause

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