Study of Visfatin Level and Its Relation to Some Histopathological Changes of Placentae in Preeclampsia

¹ Biochemistry Department, Medical Research Institute, Alexandria University, Egypt

² Pathology Department, Medical Research Institute, Alexandria University, Egypt

³ Department of Gynecology and Obstetrics, Faculty of Medicine, Benha University, Egypt

^*Corresponding Author

Magda A. Megahed

Medical Research Institute,Alexandria University

165,Elhorreya Avenue, Hadara, Alexandria

Egypt

Tel:+2034282331,+2034282373

Fax:+2034283719

Email:magda.megahad@alexu.edu.eg

Abstract

The objective of the present study was to measure the serum level of visfatin in preeclamptic Egyptian pregnant women and the possible relation of visfatin level to each of the measured insulin resistance, body mass index and histopathological changes of the placenta included in this study.

The study population consisted of 30 preeclamptic patients and 30 matched healthy pregnant women during the third trimester.

The present study results revealed that preeclamptic mothers had a significant increase in insulin resistance value than normal pregnant women with no significant difference in this value between mild and severe preeclamptic sub-groups. Regarding visfatin level, there was a highly significant increase in visfatin level in preeclamptic women compared with healthy controls and also increase in severe than mild preeclamptic sub-groups. Correlation analysis presented a significant negative correlation between maternal visfatin levels versus HOMA-IR among preeclamptic group, but no relation had been found between visfatin levels and body mass index among preeclamptic mothers. Histopathological examination of placentae revealed that infarctions, atherosis, hyalinized areas and Tenny Parkers changes were significantly increased in preeclamptic group than control group. The present study did not find any correlations between visfatin levels versus histopathological changes in placentae among preeclamptic mothers.

Hypervisfatinemia may be one of the possible etiologies of preeclampsia. Visfatin might be part of a feedback mechanism improving insulin sensitivity. Preeclamptic placentae exhibited definite histopathological changes which may be attributed to the vascular insufficiency of placenta.

Keywords:Visfatin, Preeclampsia, Insulin resistance, Placenta, Infarction

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