Sero-reactivity and Molecular Studies on Subjects with Malaria Immunity and Susceptibility in An Endemic Region

^1* Dr. Abdulazeez Aderemi ABUBAKAR,Department of Medical Laboratory Science,University of Medical Sciences , Ondo-City Nigeria.Email: aabubakar@unimed.edu.ng, Tel:+2348068039485

¹ Dr. Temidayo Daniel ADENIYI,Department of Medical Laboratory Science, University of Medical Sciences, Ondo-City, Nigeria.Email: dtemidayo@unimed.edu.ng ,Tel: +2348030612404

² Dr. Sulaiman Adebayo NASSAR,Department of Biomedical Sciences,College of Health Siences,LAUTECH,Osogbo,

Nigeria.Email: sanassar@lauthec.edu.ng, Tel: +2348053274453

³ Mrs Olubisi Janet SOLADOYE,Department of Medical Laboratory Science,Achievers University, Owo, Nigeria. Email: abuazeez1962@gmail.com , Tel: +2348094768849

^*Corresponding Author

Dr. Abdulazeez Aderemi ABUBAKAR

Department of Medical Laboratory Science

University of Medical Sciences

Ondo-City

Nigeria

Email: aabubakar@unimed.edu.ng   

Tel:+2348068039485

Abstract

Nigeria is a malaria-endemic country, yet many inhabitants of the country rarely suffer from the disease in spite of regular exposures to the vector of Plasmodium and without administration of curative or prophylactic drug. The aim of the study was to identify the subjects with resistance against malaria and conduct serological and genomic investigations their unique blood samples. One thousand two hundred and seventy (1,270) apparently healthy volunteers, aged 16-55 years participated in the study. Malaria distribution among the subjects was assessed by microscopy and serology techniques using six millilitres of the blood samples withdrawn from the subjects and questionnaire administered. Subjects with resistance against malaria were identified, their blood sera collected, tested, titrated and graded. Molecular analysis of the blood samples with respect to Fc gamma receptor IIa was conducted on malaria resistant and susceptible subjects. The study revealed 21.0% malaria infection rate by microscopy, 40.3% by serology method while 21.0% was assessed to develop natural resistance against malaria infection. Genomic analysis of blood samples from malaria resistant individuals depicted greater association with R/R131 (36.7%). The study revealed that some individuals in this locality are genetically and immunologically protected against malarial infection. Further studies on the specific genes and immunoglobulins responsible for their uniqueness are recommended.

Keywords: Malaria-immunity, Susceptibility, Sero-reactivity, Molecular, Endemic

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