Study the Oral Toxicity of Zinc Oxide Nanoparticles in Adult Mice

Medical Biophysics Department,Medical Research Institute, Alexandria University,Egypt

^*Corresponding Author

Rasha S. Shams Eldine

Medical Biophysics Department,Medical Research Institute

Alexandria University

Egypt

Email: rasha_shams17@yahoo.com

Abstract

ZnO-NPs suspended in distilled water were administered to mice at dose of 100 mg/ kg body weight through oral gavage. The mean body weight gain in mice given ZnO-NPs was similar to this of control group during the two weeks. The effects of ZnONPs on RBCs have been investigated in context with the osmotic fragility, all of the RBCs did not hemolyze at the same time when treated with ZnONPs, some RBCs took more time, and some became crenated while some remained turgid for relatively longer duration. ZnONPs can spread more in blood, kidney, liver and other organs,and this was supported by the histopathological section showed that ZnONPs is able to induce changes in tissues of kidney and liver and brain in mice. The toxic effects of zinc oxide nanoparticles on the central nervous system include cytotoxicity, inflammation, and oxidative stress induction that result in neurodegeneration.

Keywords: ZnO-NPs, Osmotic fragility, Oxidative stress

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