Association of Creatine Level and Hematological Parameters among Kidney Patients at Rwamagana Provincial Hoapital

Department of Biomedical Laboratory Sciences, Faculty of Applied Fundamental Sciences, INES-Ruhengeri, Rwanda.

^*Corresponding Author

Dr Niyonzima N. Francois

Department of BLS, Faculty of AFS, INES-Ruhengeri, Musanze-155

Rwanda

Email: niyofra@yahoo.com; fniyonzima@ines.ac.rw

Mobile phone number: +250788536610

Abstract

Kidney disease is characterized by the presence of renal damage and/or decreased renal function. It is categorized as acute kidney injury or chronic kidney disease (CKD) based on disease duration and progressiveness. Staging of CKD is based on glomerular filtration rate and albuminuria. This study was carried out at Rwamagana provincial hospital in a span of 3 months from September to November 2019. The main objective was to assess the hematological parameters among patients with kidney diseases attending the hospital. Forty-eight participants were recruited based on inclusion criteria. Blood samples were collected to perform full blood count. Hematological parameters were measured using Sysmex XS 500i. Data analysis was carried out using statistical package for social science (SPSS). The results showed that males were highly affected (70.8%) by kidney diseases in comparison to females (29.2%). Anemia, thrombocytopenia and leukopenia were the commonest associated complication to kidney diseases. The overall association with creatinine levels and hematological parameters was statistically significant (x² = 49.67, P < 0.00001). The effect of creatinine to hematological parameters at the level of creatinine (< 53 µmol/l) was statistically significant (x² = 42.18, P = < 0.00001). All hematological parameters were partially affected by creatinine levels. Thus, people at high risk for kidney diseases should be screened as it is asymptomatic in early stage..

Keywords:White blood cell, Hemoglobin, Kidney disease, Hematological parameters, Rwamagana provincial hospital

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