Comparison of Some Haemostatic Parameters in Preeclampsia Patients with Normal Pregnancy and Non-pregnant Women  

¹ Department of Medical Laboratory Science, Rivers State University, Nkpolu-Oroworukwo, Port- Harcourt, Nigeria.

^*Corresponding Author

Stella Urekweru Ken-Ezihuo

Department of Medical Laboratory Science

Rivers State University

Nkopolu-Oroworukwu,Port Harcourt

Nigeria

Tel:+2348033384477

Email:stellakenezihuo@gmail.com ken-ezihuo.stella@ust.ed.ng

Abstract

Preeclampsia is the development of gestational hypertension and significant proteinuria after 20th week of gestation, during labour or within 48 hours of delivery. This was a case control study carried out on preeclampsia patients accessing treatment at the department of obstetrics and gyneacology in the University of Port Harcourt Teaching Hospital.

Aim: The study aimed to identify possible abnormal changes in haemostatic parameters associated with established preeclampsia in pregnant women and comparing it with normal pregnancy and non-pregnant women.

Materials and Methods: A total of 90 women grouped into three participated in the study, 30 women in each group. The healthy pregnant and non- pregnant women has a systolic blood pressure between 90 and 120 mmHg and diastolic blood patients between 60 and 90 mmHg with or without protein in the urine. The preeclampsia patient had a systolic blood pressure between 140 and 190 mmHg and diastolic blood pressure 90 and 120 mmHg with or without protein in urine. Data were analyzed using Graph- Pad Prism 5.0 (ANOVA) version to get the mean and standard deviation of patients with preeclampsia, normal pregnant group and the non-pregnant group.

Results: Results were presented as means ± standard deviation. The mean of prothrombin (PT) and activated partial thromboplastin time of preeclampsia patients were significantly prolonged (P = 0.0001). There was no significant difference in mean value of fibrinogen in preeclampsia patients when compared to healthy pregnant and non-pregnant women. The result points towards a hypercoagulable state. Routine check of these parameters from the 20th week in pregnancy could be helpful to avoid the occurrence of disseminated intravascular coagulation in pregnant women.

Keywords: Preeclampsia. Blood pressure, Proteinuria, Haemostastic parameters

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